Speakers from the BAME community will be among those taking part tonight.
The vigil and minute silence has been organised by Stand Up To Racism Wales.
The socially distanced event is taking place on the green outside Swansea's Waterfront Museum.
All participants are expected to stay two metres apart and where a mask.
Elsewhere, the music industry is set to mark "Blackout Tuesday" in solidarity following the death of George Floyd in the US. You can read more on that here: https://www.thewave.co.uk/news/world-news/george-floyd-death-music-industry-blackout-announced-in-protest-over-killing/